Enhanced AT<sub>1</sub> receptor-mediated Growth Response of Cultured Mesangial Cells from Stroke-Prone SHR
نویسندگان
چکیده
منابع مشابه
Genetic subgrouping of stroke-prone SHR and stroke-resistant SHR.
From these results, we can conclude that the developmental pattern of hypertension in the young age is genetically determined and closely related to the incidence of hemorrhage or infarction. These newly selected substrains of SHRSP with higher incidences of cerebral infarction (SP-2) or hemorrhage (SP-1) are regarded as the better models for studying the pathogenesis, treatment, and prevention...
متن کاملPermeability of intracranial extracerebral vessels in stroke-prone SHR.
Permeability of intracranial extracerebral arteries of stroke-prone spontaneously hypertensive rats (SHRSP) was studied using labeling techniques (ferritin and horseradish peroxidase), at the cellular level. In the arterial endothelial cells, the tracer molecules were slowly but constantly transported by the plasmalemmal vesicles to the subendothelial space. This endothelial transportation of t...
متن کاملEffect of acute arterial hypertension in stroke-prone and stroke-resistant SHR.
Acute transient hypertension by norepinephrine was loaded to stroke-resistant (SHRSR), stroke-prone (SHRSP), and normotensive Wistar Kyoto (WK) rats. (SHRSP were most sensitive to norepinephrine in young pre-hypertensive group.) Its effects on cerebral small vessels were studied using Evans Blue to detect the increase of vascular permeability. Severe macroscopic dye-leakages were observed in th...
متن کاملAugmented expression of atrial natriuretic polypeptide gene in ventricles of spontaneously hypertensive rats (SHR) and SHR-stroke prone.
Tissue levels of atrial natriuretic polypeptide (ANP) and ANP messenger RNA (mRNA) in the atrium and ventricle were measured simultaneously in spontaneously hypertensive rats (SHR) and its substrain, SHR-stroke prone (SHRSP), and these levels were compared with those in control Wistar-Kyoto rats (WKY). At 27 weeks of age with established hypertension and ventricular hypertrophy, ANPmRNA levels ...
متن کاملEvidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells.
The possibility of Fc-dependent uptake of IgG immune complexes was examined in subcultured rat mesangial cells free of monocytes. 195Au-labeled colloidal gold particles were coated either with BSA only or with BSA followed by rabbit anti-BSA-IgG or the F(ab')2 fragment of the IgG. Mesangial cells preferentially took up 195Au particles covered with BSA-anti-BSA-IgG over those covered with BSA or...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1998
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.39.563